Cell cycle-dependent localization of Ca2+/calmodulin-dependent protein kinase II in mammalian cells
نویسندگان
چکیده
منابع مشابه
Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs.
Mouse eggs arrest at metaphase II following ovulation and are only triggered to complete meiosis when fertilized. Sperm break the cell-cycle arrest by a long-lasting series of Ca2+ spikes that lead to an activation of the anaphase-promoting complex/cyclosome. The signal transduction pathway is not fully resolved but both protein kinase C (PKC) and calmodulin-dependent protein kinase II (CamKII)...
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Hormone-receptor interactions generate signals that trigger protein kinase-catalyzed phosphorylation events (12). The action of 30 or more catecholamine and peptide hormones, as well as some prostaglandins, proceeds through parallel pathways that elevate intracellular adenosine 3’,5’-cyclic monophosphate (CAMP) and lead to activation of the CAMP-dependent protein kinase (PKA). An apparent parad...
متن کاملCa2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.
Indirect immunofluorescence was used to determine the distribution of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) in rat embryo fibroblast 3Y1 cells, rat C6 glioma cells, and human epidermoid carcinoma KB cells. During interphase at growing phase, CaM kinase II was localized diffusely in the cytoplasm and in the nucleus. In the nucleus, the enzyme was localized within the whole ...
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Protein phosphatase 1 (PP-1) is known to be a critical component of eukaryotic cell cycle progression. In vitro, our previous studies showed that cdc2 kinase phosphorylates Thr-320 (T320) in PP-1, and that this leads to inhibition of enzyme activity. To examine directly the phosphorylation of PP-1 in intact mammalian cells, an antibody has been prepared that specifically recognizes PP-1C alpha ...
متن کاملThe Function of Calcium/calmodulin Dependent Protein Kinase Ii in Cell Cycle Regulation
Ca/Calmodulin-dependent protein kinase II (CamKII) is a multifunctional enzyme that is activated by increases in intracellular Ca. CaMKII is expressed in all tissues but is most abundant in the brain. Diversity in subunit composition and Ca sensitivity permit the coordination of multiple cellular functions including muscle contraction, synaptic vesicle release, proliferation and differentiation...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)55086-7